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Myelin instability in multiple sclerosis (MS) is associated with the loss of positive charge in MBP as a result of posttranslational enzymatic deimination. This study highlights the importance of screening for large deletions in molecular studies of F11 . These results suggest that further evaluation of the wave-length spectrum of UVR and the effectiveness of sunscreen agents in prevention of UVR-induced effects on the immune system is needed. The recombinant protein was successfully expressed with the molecular weight about 60 kD, and it has good immunogenicity.

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